WBP2NL _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009259
Fusion event
HBV-WBP2NL integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2204
Orient
+
Integrated sequence
TAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTT| |GTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCA
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42443115/42047111 (Hg38)
End
42443115/42047111 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
WBP2NL
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1281/Upstream/123814; hsa-let-7a-3/Downstream/3153843;
Nearest TSS
ENST00000624155/Upstream/16565; ENST00000419475/Downstream/23719;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/47860, chr22-CpG: 55/Downstream/23292
Nearby gene
WBP2NL(-18638) ; NAGA(+11223) ;
Upstream sequence
CATACTATAGAAAACACCTGCTATTCAAAACACAACTTCTCAGTGTCATCCATTGCTGTCGTGAGAGACAACATAGCAATATCTGGTATGTTGCAAGCTT
Downstream sequence
TCAAGATAGCCTGAACTTAAAAAGTTGGTCCATTAGTTGTATCTGATGGATATATAAATTTGCCTCCTAGTTCACTTTGTGTCAAGAGCTAAAACTGTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate