Basic Information
VIS ID
TVIS10009265
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2786
Orient
+
Integrated sequence
AAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGA| |GAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGAT
Host Sequence
Chromosome
chr4
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68264799/67399081 (Hg38)
End
68264799/67399081 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1122153; hsa-mir-1243/Downstream/9174487;
Nearest TSS
ENST00000502981/Upstream/1395800; ENST00000265404/Downstream/21973;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1728125, chr4-CpG: 37/Downstream/146194
Nearby gene
EPHA5-AS1(-1705695) ; CENPC(+73190) ;
Upstream sequence
attccattccattccattccattccactcgtgttgattcccttccattccattccattccattccacttgtgttgattccattccgttcctttcgattgc
Downstream sequence
agtttctgagaatgattctgtctactttttatacgaagatatttccttttctacttttggcctataagcgcttgaaatctccaacttcaaatatcacaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate