Basic Information
VIS ID
TVIS10009272
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
707
Orient
+
Integrated sequence
CCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGT| |AGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCA
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
144370022/143287852 (Hg38)
End
144370022/143287852 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA8D
Nearest miRNA
hsa-mir-1204/Upstream/1111434; hsa-mir-10400/Downstream/445231;
Nearest TSS
ENST00000518652/Upstream/6162; ENST00000521537/Downstream/1824;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/4038, chr8-CpG: 45/Downstream/1424
Nearby gene
GLI4(-10921) ; ZNF696(+3537) ;
Upstream sequence
GGTAATGCAAAAAGTCACAATACAGCTAGAAACAAAAGCGAAACTGACCCAGGAAATTTGTTAACTGTCCAAGCTGAATGACATGCAAAATATAAACAAA
Downstream sequence
cggtcaggtctttcccttcccacgaggccatatttcagactgtcacatggggagaaaccctggacaatacctggttttcctaggcagaggacccggcggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate