Basic Information
VIS ID
TVIS10009274
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1802
Orient
-
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
106256997/103494715 (Hg38)
End
106256997/103494715 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/5265498; hsa-mir-12126/Downstream/3106213;
Nearest TSS
ENST00000422679/Upstream/64823; ENST00000647310/Downstream/505040;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1755921, chr9-CpG: 38/Downstream/504634
Nearby gene
CYLC2(-476227) ; SMC2(+599544) ;
Upstream sequence
ctttgggaggccgaggcgggcggatcacaaggtcaggagatcgagaccatcttggctaacacggtgaaaccccgtctctactaaaaatacaaaaaattag
Downstream sequence
GATTTATAAATGCTTGTCACACCAATAAAGTTCGATCATTTAAGTATTTTCTAATTAGGTAAAGGTTAAAGTCAAGCTTGGTTAATAAAATCCTTAGGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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