Basic Information
VIS ID
TVIS10009295
Fusion event
HBV-NR1H5P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1729
Orient
-
Integrated sequence
CCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAA| |GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA
Host Sequence
Chromosome
chr1
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
115382910/114840289 (Hg38)
End
115382910/114840289 (Hg38)
Orient
-
Location type
Intronic
Target gene
NR1H5P
Nearest miRNA
hsa-mir-101-1/Upstream/1958160; hsa-mir-1182/Downstream/1719735;
Nearest TSS
ENST00000473358/Upstream/59604; ENST00000468191/Downstream/14514;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/59448, chr1-CpG: 37/Downstream/14538
Nearby gene
SIKE1(-59602) ; SYCP1(+14545) ;
Upstream sequence
atcttcccacctcagccttccaaagtgctgggattacaggcatcccatcatgcccagcTAATTTTTCTTTAAAGAGTACTATTAATGTTTTCTTTTCATG
Downstream sequence
TCTAATCTAGCCTTGTTCAAACTCTTATTATTTTGCATTTATGCTATAATATTAGTTTCCTGGCCATTTCTTCCTTCTCTCTTTTTGGTCAATCTATCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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