Basic Information
VIS ID
TVIS10009297
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1479
Orient
-
Integrated sequence
CTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGG| |GACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCG
Host Sequence
Chromosome
chr1
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
167105600/167136363 (Hg38)
End
167105600/167136363 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/981565; hsa-mir-1182/Downstream/862297;
Nearest TSS
ENST00000473358/Upstream/10444; ENST00000559038/Downstream/30116;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/14590, chr1-CpG: 193/Downstream/83530
Nearby gene
DUSP27(-7198) ; POU2F1(+84466) ;
Upstream sequence
GGGAGGGAAAAAAAAGCAGCTCCAAAGGCCATCATGGTAATAATTGGTCCTAGCCCTGCCCTGTGCCATGCCAGCTGCAACCAGCCTGCTGTGACCTCAT
Downstream sequence
TCACACGAAATGGCTAAGAGCTGTTCTGGGGGAACCAGACATTCCTCAAAGGAACACAGAGTAACTAAAACCCCTGTGGCAAGCAAAAGGGCAGACAGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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