Basic Information
VIS ID
TVIS10009298
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3145
Orient
+
Integrated sequence
GGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCC| |ACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr1
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
167107591/167138354 (Hg38)
End
167107591/167138354 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/983556; hsa-mir-1182/Downstream/860306;
Nearest TSS
ENST00000473358/Upstream/12435; ENST00000559038/Downstream/28125;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16581, chr1-CpG: 193/Downstream/81539
Nearby gene
DUSP27(-9189) ; POU2F1(+82475) ;
Upstream sequence
CCAGGGGCTACTTCGGCTTTAAATCCCAGTGTTACACTCAATCCTTTGAGTTAAAGCCTCAGCTGCGGTTAAAAAGTCTGTGAATTAGGGGTAACTCAGT
Downstream sequence
GGCATGGATTAGCCAGGATCTCTTTGAAAAGAGGACACCCAGACAGTAAGTTTTGATGGAGGAATATCAAAAGGTCCAGGAGCCTGCAAGTTGTGTCAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate