VISDB Viral Integration Site DataBase

VIS ID

TVIS10009299

Fusion event

HBV-ENAH integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

748

Orient

-

Integrated sequence

TGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGA| |TGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAA

Chromosome

chr1

Cytoband

q42.12

Reference genome

Start

End

225789025/225601323 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-615-3p ; hsa-mir-375 ; hsa-mir-142-3p ; hsa-mir-124-3p ; hsa-mir-181a-5p ; hsa-mir-21-5p ; hsa-mir-93-3p ; hsa-mir-193b-3p ; hsa-mir-191-5p ; hsa-mir-196a-5p ; hsa-mir-4282 ; hsa-mir-219b-5p ; hsa-mir-3145-3p ; hsa-mir-548c-3p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-203a-3p ; hsa-mir-5680 ; hsa-mir-3200-5p ; hsa-mir-590-3p ; hsa-mir-618 ; hsa-mir-548p ; hsa-mir-2278 ; hsa-mir-665 ; hsa-mir-1273e ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-7160-5p ; hsa-mir-873-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6832-3p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-4478 ; hsa-mir-3929 ; hsa-mir-4419b ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6854-3p ; hsa-mir-629-3p ; hsa-mir-548aw ; hsa-mir-4279 ; hsa-mir-6881-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-877-3p ; hsa-mir-7109-3p ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-3613-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-378a-5p ; hsa-mir-6131 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-323b-3p ; hsa-mir-433-5p ; hsa-mir-488-3p ; hsa-mir-6815-3p ; hsa-mir-103a-2-5p ; hsa-mir-4778-3p ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-3158-3p ; hsa-mir-3154

Nearest miRNA

hsa-mir-101-1/Upstream/1203012; hsa-mir-1182/Downstream/320757;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/125984, chr1-CpG: 168/Downstream/51245

Upstream sequence

GAAGGTTCCAATTACggccaggcacggtggctcacgcctgtaatcccagcagtttgggaggccgaggtgggcggatcacgatgtcaggagattgagacca

Downstream sequence

tcctggctaacagtgaaaccccgtgtctactaaaaatacaaaaaattagccgggtgtggtggcggacgcatgtagtcccagctacttgggaggctgaggc