Basic Information
VIS ID
TVIS10009300
Fusion event
HBV-LOC105373162 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1791
Orient
-
Integrated sequence
CCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA| |TAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
230001376/229865629 (Hg38)
End
230001376/229865629 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
LOC105373162
Nearest miRNA
hsa-mir-101-1/Upstream/1403477; hsa-mir-1182/Downstream/1154199;
Nearest TSS
ENST00000473358/Upstream/214782; ENST00000445339/Downstream/20123;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/239077, chr1-CpG: 171/Downstream/201118
Nearby gene
URB2(-205430) ; GALNT2(+201580) ;
Upstream sequence
tggcgggccccgcactcggagcggccggccggccctgcggccccgggctgtgaggggcttagcacccgggccagtggctgcggagggtgtactgggtccc
Downstream sequence
ccagcagtgccagcctgccggcgctgcgctcgatttctcaccgggccttagctgccttcccacggggcagggctcgggacctgcagcccgccatgcctga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate