Basic Information
VIS ID
TVIS10009307
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
15795247/15753248 (Hg38)
End
15795247/15753248 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/1316587; hsa-mir-107/Downstream/2091859;
Nearest TSS
ENST00000439456/Upstream/33123; ENST00000434386/Downstream/29087;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/33146, chr10-CpG: 29/Downstream/106832
Nearby gene
ITGA8(-33477) ; MINDY3(+24928) ;
Nearest cancer related gene
MINDY3(TSG, +24928) ;
Upstream sequence
gtaatcccaggactttgggaggccaagtcttcaattgcttgaggccaggagtcggagactagcttgggtaacgtagtgagacccagtatctacaaagaat
Downstream sequence
gatctgggtgtggtggtacacacctgtagtcacagttactcaggaggctgaggcaggaggatcacttgagcccagcagtttgtggctgcagtgagccatg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate