Basic Information
VIS ID
TVIS10009310
Fusion event
HBV-SHLD2P1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1946
Orient
-
Integrated sequence
CTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTT| |ACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGT
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
46921812/46627803 (Hg38)
End
46921812/46627803 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10G
Target gene
SHLD2P1
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-1265/Upstream/1463715; hsa-mir-107/Downstream/2357709;
Nearest TSS
ENST00000439456/Upstream/16682; ENST00000605984/Downstream/4584;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/48178, chr10-CpG: 38/Downstream/7797
Upstream sequence
gaaatgcaaactggcagaacctttcttgaggataactgacaattaatatgaacaaattgggggtacttttagcccaataattttagctctaggaacttat
Downstream sequence
cataactatgtataaagatgtagctgaaaatgggtttatcatggtatcatgtataattgtgaaaaataaaaaacaaccagagtccctcaaaatagaggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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