Basic Information
VIS ID
TVIS10009311
Fusion event
HBV-SHLD2P3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1946
Orient
-
Integrated sequence
CTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTT| |ACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGT
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
47403881/47713861 (Hg38)
End
47403881/47713861 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10G
Target gene
SHLD2P3
Nearest miRNA
hsa-mir-1265/Upstream/2549773; hsa-mir-107/Downstream/1271651;
Nearest TSS
ENST00000439456/Upstream/114031; ENST00000576178/Downstream/48846;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/7793, chr10-CpG: 127/Downstream/48322
Upstream sequence
gaaatgcaaactggcagaacctttcttgaggataactgacaattaatatgaacaaattgggggtacttttagcccaataattttagctctaggaacttat
Downstream sequence
cataactatgtataaagatgtagctgaaaatgggtttatcatggtatcatgtataattgtgaaaaataaaaaacaaccagagtccctcaaaatagaggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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