Basic Information
VIS ID
TVIS10009325
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2481
Orient
+
Integrated sequence
TCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAA| |CTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAA
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
132193913/131709368 (Hg38)
End
132193913/131709368 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12E
Nearest miRNA
hsa-let-7i/Upstream/3415190; hsa-mir-6763/Downstream/872629;
Nearest TSS
ENST00000382841/Upstream/46772; ENST00000535399/Downstream/1713;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/22711, chr12-CpG: 121/Downstream/1121
Nearby gene
LINC01257(-496437) ; SFSWAP(+1719) ;
Upstream sequence
aagcacctgcatctgtttagtcactgttcccagaggtcatcattgagggaataggggggccttcagatcccatttctgacaccaGAACtgttaaaagaga
Downstream sequence
aactttacacaaaacaaattcgagtttattcgagcaagaaaacaattcatgaatcaggcagcatgcagaagcagaagaggttcagagagttccactcagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate