Basic Information
VIS ID
TVIS10009329
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2061
Orient
+
Integrated sequence
TTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACT| |GCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCA
Host Sequence
Chromosome
chr13
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
34282246/33708109 (Hg38)
End
34282246/33708109 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-2276/Upstream/9545605; hsa-mir-1267/Downstream/5955925;
Nearest TSS
ENST00000623511/Upstream/31341; ENST00000380071/Downstream/109940;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/165106, chr13-CpG: 38/Downstream/109881
Nearby gene
STARD13(-31314) ; RFC3(+109960) ;
Nearest cancer related gene
STARD13(TSG, -31314) ; RFC3(OG, +109960) ;
Upstream sequence
TGGGCCACTTTGATATCTGCTGTTAGACAGAGGCTAGAGAGCCTTGTTTTGTCTCAGAGGGGTATGCATCACCCAGCAAGTTCTCTCAAACATAGGATAG
Downstream sequence
TTCCCCAGCTGCAGCAGAAGTGGCCAGAGCTGAGACTATACCACTTCAGGATCTCTTCTGGATGGAGGATGGCATGCTTGTTACATTGGCTTAGATAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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