Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009337
Fusion event
HBV-HYDIN integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr16
Cytoband
q22.2
Reference genome
Start
End
71147139/71113236 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-1225/Upstream/1082814; hsa-mir-11401/Downstream/5755700;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/311841, chr16-CpG: 29/Downstream/117221
Upstream sequence
GAAGGGGAAAAACCTAGGAACCgaaaagtgaactaaaccctcatctttcatactggggcgtcaaaagaaaatgtacgaagttaataaatccaccaaaagc
Downstream sequence
aacataagcatagagctggcaagggaaaccaccatcacaagaaacagccaaaagaagtttttggaagtagCAGTGGTGACACAGACTAACATTTAGCTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.