Basic Information
VIS ID
TVIS10009338
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
582
Orient
-
Integrated sequence
AATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCT| |TCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTAC
Host Sequence
Chromosome
chr17
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
25279701/26952675 (Hg38)
End
25279701/26952675 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/7608101; hsa-mir-10226/Downstream/341235;
Nearest TSS
ENST00000595228/Upstream/4259841; ENST00000583786/Downstream/47250;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/176862, chr17-CpG: 114/Downstream/9786
Nearby gene
MIR4522(+341235) ;
Upstream sequence
gaaaaaggaaagaaagcaaggaagtgagaaagaaagaataagagaaaagaaggaagaaaagaagggagggacaaaggaagggagggaggagggaaggaag
Downstream sequence
aatcagaggaaaggaagcaaagaaggaaggaagaaaaaaagaaaaagaaaggaaaagaaaaagaaaagaaagaggaaaagaagaaaggaaggaagaaggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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