Basic Information
VIS ID
TVIS10009339
Fusion event
HBV-LOC100130370 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1627
Orient
-
Integrated sequence
GCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAAC| |GCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTA
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
79363064/81389264 (Hg38)
End
79363064/81389264 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC100130370
Nearest miRNA
hsa-mir-10226/Upstream/255956; hsa-mir-3186/Downstream/11452;
Nearest TSS
ENST00000595228/Upstream/1849; ENST00000583828/Downstream/860;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/1341, chr17-CpG: 653/Downstream/3742
Nearby gene
TMEM105(-58590) ; BAHCC1(+10476) ;
Upstream sequence
TGGATTGGTCCTGCCTGAGCATTGTCCCCAAGCAGGGCAGTTTCAGCCACTAGGCCCTCCCAACCCCCATCTGTCTGATCTGGGCTTTCTCTCCCGGGTC
Downstream sequence
TGGCTTCCTGTCCTCATCCTCATGGGCAGGAAGACGGAGGGCTGTTTCGGGTCAACCTCCTGTAAGGAAAACCGATTACTCTTTATTCCAGCAGATCCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate