Basic Information
VIS ID
TVIS10009340
Fusion event
HBV-POTEC integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1935
Orient
+
Integrated sequence
CCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCT| |ACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTC
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
14532134/14532135 (Hg38)
End
14532134/14532135 (Hg38)
Orient
+
Location type
Intronic
Target gene
POTEC
Nearest miRNA
hsa-mir-3976/Upstream/920935; hsa-mir-1-2/Downstream/298031;
Nearest TSS
ENST00000575820/Upstream/399645; ENST00000579292/Downstream/11011;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/44649, chr18-CpG: 59/Downstream/215382
Upstream sequence
CATATGGGACTTTCTACTGCCTAAGGTTCTACACAGGATATAAAGGTGCCTCACAGTATAGATCTGGTAGCAAAGAAGAAGAAACAAACACTGATCTCTT
Downstream sequence
TCTGCCACATTATTTGAACCCCTCTGACCCTTTATAACAAGCCCACCTCATATCTGCTAGAGAAAAGACCAACAACGGCCTGAAAGGATCTCTTACCATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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