Basic Information
VIS ID
TVIS10009344
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|
Start
3040
Orient
-
Integrated sequence
ATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTT| |GGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTG
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
End
56872699/59205467 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-1-2/Upstream/754309; hsa-mir-5011/Downstream/7876117;
Nearby gene
SEC11C(-46636) ; GRP(+14701) ;
Upstream sequence
gcactttatgcaaacagtcaggccaaatatgaaagtaaagtctatttttcaaaccgctcagtcctatgatgatacgttttttaaacaaaaatgaggactg
Downstream sequence
gagagagagaaattatatttcaaaacttataatacatttgtcattaaattccaaactcactagttgtttttaatattttgcctacattttacactaaccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate