VISDB Viral Integration Site DataBase

VIS ID

TVIS10009347

Fusion event

HBV-NUCB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1816

Orient

-

Integrated sequence

CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC

Chromosome

chr19

Cytoband

q13.33

Reference genome

Start

End

49412903/48909646 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-484 ; hsa-mir-92a-3p ; hsa-mir-4762-3p ; hsa-mir-1303 ; hsa-mir-744-3p ; hsa-mir-4303 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-4781-3p ; hsa-mir-483-5p ; hsa-mir-6131 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3663-5p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3152-5p ; hsa-mir-3942-3p ; hsa-mir-6881-3p ; hsa-mir-6836-3p ; hsa-mir-1248 ; hsa-mir-877-3p ; hsa-mir-3614-3p ; hsa-mir-1245b-3p ; hsa-mir-1293 ; hsa-mir-3199 ; hsa-mir-363-5p ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-4483 ; hsa-mir-4515 ; hsa-mir-4648 ; hsa-mir-5008-5p ; hsa-mir-6089 ; hsa-mir-6730-5p ; hsa-mir-6733-3p ; hsa-mir-6745 ; hsa-mir-6748-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-8052 ; hsa-mir-1273e ; hsa-mir-1537-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3612 ; hsa-mir-3664-3p ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4499 ; hsa-mir-4523 ; hsa-mir-455-3p ; hsa-mir-4649-3p ; hsa-mir-4695-5p ; hsa-mir-4722-5p ; hsa-mir-4768-3p ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-545-5p ; hsa-mir-5690 ; hsa-mir-6086 ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6808-5p ; hsa-mir-6857-3p ; hsa-mir-6893-5p ; hsa-mir-873-3p ; hsa-mir-940 ; hsa-mir-143-3p ; hsa-mir-31-3p ; hsa-mir-4735-5p ; hsa-mir-4770 ; hsa-mir-4775 ; hsa-mir-590-3p ; hsa-mir-6088

Nearest miRNA

hsa-mir-10395/Upstream/1682625; hsa-let-7e/Downstream/100260;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/9285, chr19-CpG: 37/Downstream/23792

Upstream sequence

TAttattattttgagacagggtttcacttctatcctccaggctagagtgcagtggtgcgatctcggctcactgcatcctccccctcccacgctcaagtga

Downstream sequence

ttctcctgccttagcctcctgagcagctgggactacaggcacacaccactgcacacagctaatttttatattttttgtagagatggggtttcaccatgtt