VISDB Viral Integration Site DataBase

VIS ID

TVIS10009353

Fusion event

HBV-chr2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1762

Orient

-

Integrated sequence

GACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTA| |AAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTAC

Chromosome

chr2

Cytoband

q33.1

Reference genome

Start

End

198367867/197503143 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

HSPE1 ; HSPE1-MOB4

miRNAs that regulate target gene

hsa-let-7f-2-3p ; hsa-mir-101-3p ; hsa-mir-383-5p ; hsa-mir-569 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-2053 ; hsa-mir-4772-5p ; hsa-mir-5011-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-219a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-508-3p ; hsa-mir-580-5p ; hsa-mir-590-3p ; hsa-mir-640 ; hsa-mir-374b-3p ; hsa-mir-4445-5p ; hsa-mir-4524a-5p ; hsa-mir-4782-3p ; hsa-mir-4524b-5p ; hsa-mir-6766-3p ; hsa-mir-6838-5p ; hsa-mir-3662 ; hsa-mir-2681-5p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-550b-2-5p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-210-5p ; hsa-mir-1233-3p ; hsa-mir-6889-3p ; hsa-mir-1225-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-1914-5p ; hsa-mir-6504-3p ; hsa-mir-512-3p ; hsa-mir-6769a-3p ; hsa-mir-4438 ; hsa-mir-4711-3p ; hsa-mir-944 ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-144-3p ; hsa-mir-632 ; hsa-mir-4288 ; hsa-mir-6888-3p ; hsa-mir-5001-3p ; hsa-mir-378a-5p ; hsa-mir-346 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3120-5p ; hsa-mir-3653-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-6843-3p ; hsa-mir-6848-3p ; hsa-mir-5587-5p ; hsa-mir-6801-5p ; hsa-mir-6131 ; hsa-mir-3663-5p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a

Nearest miRNA

hsa-mir-10b/Upstream/8370032; hsa-mir-1244-1/Downstream/9280091;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/2462, chr2-CpG: 83/Downstream/12556

Upstream sequence

AGAGATTCAACCAGTTAGCGTGAAAGTTGGAGATAAAGTTCTTCTCCCAGAATATGGAGGCACCAAAGTAGTTCTAGATGACAAGGTGTGTAAACTTAAT

Downstream sequence

AATTCTAAAAAGAAGTCAGATATTTGCAATTAGTTGTCTTAACTAATGGTTTTTTTCACTTGCAGGATTATTTCCTATTTAGAGATGGTGACATTCTTGG