VISDB Viral Integration Site DataBase

VIS ID

TVIS10009355

Fusion event

HBV-ERBB4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1728

Orient

-

Integrated sequence

CCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAA| |AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC

Chromosome

chr2

Cytoband

q34

Reference genome

Start

End

212717992/211853267 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-372-3p ; hsa-mir-19a-3p ; hsa-mir-302d-3p ; hsa-mir-146a-5p ; hsa-mir-145-5p ; hsa-mir-221-3p ; hsa-mir-302b-3p ; hsa-mir-193a-3p ; hsa-mir-146b-5p

Nearest miRNA

hsa-mir-10b/Upstream/4098386; hsa-mir-1244-1/Downstream/572996;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/1376455, chr2-CpG: 86/Downstream/684189

Nearest cancer related gene

ERBB4(OG, No orient, 0)

Upstream sequence

TTTTAGGCTGGAAATAGAGATCAGATTCTTGCATAATTGTGTGAAAGAGACTGAATCATCAACAGATCTTGCTCTTTTTTTTTCTTCACTTACCTATAGT

Downstream sequence

ACATCAATGAGTGAATAGGTCCAGAGTGAGCAGTCTATGTTGCCTTTCTTTTAACTGGGAATCCATTCTCTATGCATTTTAGGTCAAAACGTTTATTCCA