Basic Information
VIS ID
TVIS10009364
Fusion event
HBV-MIR99AHG integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1729
Orient
-
Integrated sequence
CCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAA| |GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17714056/16341735 (Hg38)
End
17714056/16341735 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA21A
Target gene
MIR99AHG
Nearest miRNA
hsa-mir-10396a/Upstream/2617461; hsa-let-7c/Downstream/197354;
Nearest TSS
ENST00000624081/Upstream/11131; ENST00000435697/Downstream/77345;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/611251, chr21-CpG: 138/Downstream/1170753
Nearest cancer related gene
MIR99AHG(OG, No orient, 0)
Upstream sequence
tcttgaaaaagcttctaaattcttaatttgtatacttactttgtcccagataggtaatgaatagtttgctgagaggcaccactctcagtccacactcagg
Downstream sequence
gtaacactgTATTAGTGCACATAAAAATAAGGTACAACTGAATCAAAAAAAAGGATCttgtagatgctagagatacaacagtgaacagaccaaaggtccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate