Basic Information
VIS ID
TVIS10009369
Fusion event
HBV-LOC105374196 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
109
Orient
+
Integrated sequence
ACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCT| |CTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGG
Host Sequence
Chromosome
chr3
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
166801895/167084107 (Hg38)
End
166801895/167084107 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374196
Nearest miRNA
hsa-let-7g/Upstream/2912551; hsa-mir-1224/Downstream/1467747;
Nearest TSS
ENST00000440867/Upstream/239151; ENST00000498413/Downstream/198214;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/3079600, chr3-CpG: 23/Downstream/296032
Nearby gene
BCHE(-1246642) ; ZBBX(+156182) ;
Upstream sequence
gttagggttagggatgtgggtgagggtgaggatgaaggttagggttagggttagggttagggttagggttagggttagggttagggttagggttaggggt
Downstream sequence
TTCTTCCAAAAATCTCTAGTCCTGCGCTGACAATAACAAGAAGCAGGTCTGAATTGGAGTTTTAGAAGAAAAGCATTTTCTGTTTGAACTCACTTTCACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate