VISDB Viral Integration Site DataBase

VIS ID

TVIS10009370

Fusion event

HBV-ADH1B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

188

Orient

-

Integrated sequence

ACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACC| |CCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGA

Chromosome

chr4

Cytoband

q23

Reference genome

Start

End

100230355/99309198 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-4758-3p ; hsa-mir-3189-5p ; hsa-mir-5699-5p ; hsa-mir-5011-5p ; hsa-mir-4280 ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4705 ; hsa-mir-4666a-3p ; hsa-mir-5580-3p ; hsa-mir-34b-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-568 ; hsa-mir-3924 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p

Nearest miRNA

hsa-mir-12113/Upstream/311738; hsa-mir-1243/Downstream/1931597;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/220220, chr4-CpG: 40/Downstream/254372

Upstream sequence

attccgttcaattccattgcattccattccattccattccactcgggtggattccattccattccattccattccattccattccattccattccattcc

Downstream sequence

atgtttgactagttgattatttctgtagaatagatttctagaaatggaattgctggggcaaaggattcagttattttttaaaggtttctgatatatatta