VISDB Viral Integration Site DataBase

VIS ID

TVIS10009373

Fusion event

HBV-KLB integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1777

Orient

-

Integrated sequence

AGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTA| |GGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAA

Chromosome

chr4

Cytoband

p14

Reference genome

Start

End

39409667/39408047 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-34a-5p ; hsa-mir-93-5p ; hsa-mir-4446-5p ; hsa-mir-6814-5p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p ; hsa-mir-4780 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-7641 ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-4695-3p ; hsa-mir-3663-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-1306-5p ; hsa-mir-4781-3p ; hsa-mir-483-3p ; hsa-mir-6872-3p

Nearest miRNA

hsa-mir-12113/Upstream/539920; hsa-mir-1243/Downstream/3863;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/41454, chr4-CpG: 77/Downstream/38517

Upstream sequence

ttccattccattcctttccattgcattccattccattgcattccattccattccattccatttcattccattctattccattccgttccattccattcgt

Downstream sequence

ACTTTCATTCTGTGGGAAAACAGTGCTTCATAAATTTAATTGTTGGAACCCTTTTCTGACAACATGCAATCATTTCAGAATTATCTTAAGGCACAACCAT