VISDB Viral Integration Site DataBase

VIS ID

TVIS10009374

Fusion event

HBV-KLB integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2616

Orient

+

Integrated sequence

TTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGA| |GAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACAT

Chromosome

chr4

Cytoband

p14

Reference genome

Start

End

39409707/39408087 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-34a-5p ; hsa-mir-93-5p ; hsa-mir-4446-5p ; hsa-mir-6814-5p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p ; hsa-mir-4780 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-7641 ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-4695-3p ; hsa-mir-3663-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-1306-5p ; hsa-mir-4781-3p ; hsa-mir-483-3p ; hsa-mir-6872-3p

Nearest miRNA

hsa-mir-12113/Upstream/539960; hsa-mir-1243/Downstream/3823;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/41494, chr4-CpG: 77/Downstream/38477

Upstream sequence

tccattccatgccattccactcgggttgtttcccttttgttgtattccattccattccattccattccattccattccattccattccattccattcctt

Downstream sequence

TGTTGGAACCCTTTTCTGACAACATGCAATCATTTCAGAATTATCTTAAGGCACAACCATTTCAAATATGTATTTGTTGTTAAGTATAGCTAACTTAGCT