Basic Information
VIS ID
TVIS10009379
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
164836610/165409605 (Hg38)
End
164836610/165409605 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/4924155; hsa-mir-103a-1/Downstream/2756240;
Nearest TSS
ENST00000502646/Upstream/60575; ENST00000520075/Downstream/718893;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1903665, chr5-CpG: 17/Downstream/1568874
Nearby gene
MAT2B(-1890282) ; TENM2(+1875233) ;
Upstream sequence
taaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaac
Downstream sequence
TATGCATGGGCAGGTTACACTAAGTCACCAAAGAGGGAAAATGTTGAAAAAAGAGAGGAGGAAAATAAACCTACTTGTAAATTCTCGGTTTTAATATTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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