Basic Information
VIS ID
TVIS10009380
Fusion event
HBV-LOC105377706 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2005
Orient
-
Integrated sequence
GACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCT| |CAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCT
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
166302893/166875888 (Hg38)
End
166302893/166875888 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105377706
Nearest miRNA
hsa-mir-10397/Upstream/6390438; hsa-mir-103a-1/Downstream/1289957;
Nearest TSS
ENST00000502646/Upstream/747390; ENST00000517586/Downstream/50482;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/3369948, chr5-CpG: 17/Downstream/102591
Nearby gene
TENM2(+408950) ;
Upstream sequence
taaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaac
Downstream sequence
TTAAAAGCTGGGACATGGAGCAGGCAAATGCATAATCTGGAAATTAGAGAAAATATTCACAAAAAGAGAATATAACAAAGACTGTGTTTTTAGATCTAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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