VISDB Viral Integration Site DataBase

VIS ID

TVIS10009385

Fusion event

HBV-SASH1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

406

Orient

+

Integrated sequence

CAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCC| |TCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAG

Chromosome

chr6

Cytoband

q24.3

Reference genome

Start

End

148692662/148371526 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-93-5p ; hsa-mir-181a-5p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-3944-5p ; hsa-mir-548q ; hsa-mir-8083 ; hsa-mir-4700-3p ; hsa-mir-4744 ; hsa-mir-4773 ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-7156-3p ; hsa-mir-1262 ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-4325 ; hsa-mir-4504 ; hsa-mir-4701-3p ; hsa-mir-508-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6736-5p ; hsa-mir-6742-3p ; hsa-mir-6776-5p ; hsa-mir-6849-3p ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-92a-3p ; hsa-mir-92b-3p

Nearest miRNA

hsa-mir-10398/Upstream/7687643; hsa-mir-1202/Downstream/2731149;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/28447, chr6-CpG: 44/Downstream/188354

Nearest cancer related gene

SASH1(TSG, No orient, 0)

Upstream sequence

cctggtgggaggtcattgaatcatgggggcaattacctccatgctgttcttgtgatagctgagtgagttctcacgagatctgatggttctctctgccacc

Downstream sequence

caaagtgttgggattacaggcgtgagccactgtgctcagcTGCCTTGTTGGCTCTTCTGCAGTTTAGCATGAGAGTCATGTCAGGTCCCCACTGCCACTC