Basic Information
VIS ID
TVIS10009386
Fusion event
HBV-GSTA7P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
264
Orient
+
Integrated sequence
CATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGG| |ACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTC
Host Sequence
Chromosome
chr6
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
52609720/52744922 (Hg38)
End
52609720/52744922 (Hg38)
Orient
+
Location type
ncRNA_exonic
Target gene
GSTA7P
Nearest miRNA
hsa-mir-10398/Upstream/595881; hsa-mir-10524/Downstream/532071;
Nearest TSS
ENST00000381078/Upstream/73813; ENST00000461222/Downstream/18647;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/73732, chr6-CpG: 19/Downstream/249845
Upstream sequence
gtgggaggtcattgaatcatgggggcaattacctccatgctgttcttgtgatagctgagtgagttctcacgagatctgatggttctctctgccaccatgt
Downstream sequence
TGTTTTGAGAGGGGATGTCAATGGAGAGATGGCACTGAGCAGTTCTTCTACTTATGGTGTTGTCATATCTTAGGAAAGCCTGTGTCTCCAAGTGAGATCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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