VISDB Viral Integration Site DataBase

VIS ID

TVIS10009387

Fusion event

HBV-PABPC1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

430

Orient

+

Integrated sequence

AATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCA| |TCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCAT

Chromosome

chr8

Cytoband

q22.3

Reference genome

Start

End

101731602/100719374 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-125b-5p ; hsa-mir-30a-5p ; hsa-mir-1295a ; hsa-mir-744-5p ; hsa-mir-423-5p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-181a-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-let-7b-5p ; hsa-mir-34c-5p ; hsa-mir-1256 ; hsa-mir-5588-5p ; hsa-mir-4720-5p ; hsa-mir-4799-3p ; hsa-mir-8088 ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-561-3p ; hsa-mir-3684 ; hsa-mir-631 ; hsa-mir-3661 ; hsa-mir-3124-3p ; hsa-mir-449c-3p ; hsa-mir-4307 ; hsa-mir-1227-3p ; hsa-mir-4252 ; hsa-mir-6499-3p ; hsa-mir-2467-3p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4537 ; hsa-mir-17-3p ; hsa-mir-1273g-3p ; hsa-mir-6505-3p ; hsa-mir-617 ; hsa-mir-4705 ; hsa-mir-888-3p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p

Nearest miRNA

hsa-mir-12123/Upstream/16350; hsa-mir-10400/Downstream/1406058;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/69690, chr8-CpG: 191/Downstream/1611

Upstream sequence

CACGGGAGTTGGACAAAAGAGGACTTTACAAAATGGCCTATAggctgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgaggcgggcg

Downstream sequence

CTCAGCTTCCCTAGTTTTTTTTTTTTTTTAGCTGACTTTGCTTGAGCTATTTTTCAATGAGTCACCTCTTCCTATGAAATTGAAAACTGGTCACTTTCAG