Basic Information
VIS ID
TVIS10009391
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1796
Orient
-
Integrated sequence
CTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAAT| |TGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTT
Host Sequence
Chromosome
chrX
Cytoband
p22.32
Reference genome
GRCh37/hg19
Start
5136964/5218923 (Hg38)
End
5136964/5218923 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3690-1/Upstream/2609669; hsa-let-7f-2/Downstream/1164983;
Nearest TSS
ENST00000429181/Upstream/585351; ENST00000217961/Downstream/507034;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1297901, chrX-CpG: 21/Downstream/674043
Nearby gene
LOC389906(-1375029) ; NLGN4X(+671119) ;
Upstream sequence
gttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggtga
Downstream sequence
TCTAATTTTGGGTATATAAGTGGGAGATAGCCATACATCACACAAGATCTGGGGTAAGCATTGTATTCATTATTGAGCCACTTAAAAGATGTCTTCACCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate