Basic Information
VIS ID
TVIS10009392
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
103106759/101347002 (Hg38)
End
103106759/101347002 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/371918; hsa-mir-1307/Downstream/254415;
Nearest TSS
ENST00000439456/Upstream/23608; ENST00000475200/Downstream/7031;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/36255, chr10-CpG: 69/Downstream/6764
Nearby gene
BTRC(+7031) ;
Upstream sequence
ccagctaatttttgtgtttttagtagagacggggtttcaccatattggccaggctggtcttgaactcctgacctctggtgatccacccacctcagcctct
Downstream sequence
gaaagtgctgggattacaggcatgagccactgcgcccagccGGaaagctacttttggatccagcaatcccacttcccaaatgaattgaaatcagtgtgtc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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