Basic Information
VIS ID
TVIS10009399
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
52919750/54303211 (Hg38)
End
52919750/54303211 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/234726; hsa-mir-1-1/Downstream/3018291;
Nearest TSS
ENST00000382410/Upstream/94783; ENST00000491469/Downstream/172386;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/94702, chr20-CpG: 96/Downstream/171983
Nearby gene
PFDN4(-83258) ; DOK5(+172516) ;
Upstream sequence
ccagctaatttttgtatttttagtagagacggggtttcaccatgttggccaggctggcctcgaactcctgaactcaggtgatccacccgcctcagcctct
Downstream sequence
gaaagtgctgggattacaggcatgagccactgcgcccagcAAGGAAGGTCTTTTTCATTATTCTCGCTCTGGGGCTCAGGTGTCTGGTAGTTACACATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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