VISDB Viral Integration Site DataBase

VIS ID

TVIS10009401

Fusion event

HBV-UBE2D3 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1765

Orient

-

Integrated sequence

TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT

Chromosome

chr4

Cytoband

q24

Reference genome

Start

End

103762567/102841410 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-101-3p ; hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-mir-877-3p ; hsa-mir-423-5p ; hsa-mir-218-5p ; hsa-mir-136-5p ; hsa-mir-6126 ; hsa-mir-6864-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-3934-3p ; hsa-mir-3670 ; hsa-mir-539-5p ; hsa-mir-493-3p ; hsa-mir-4635 ; hsa-mir-3664-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-4453 ; hsa-mir-4538 ; hsa-mir-6854-5p ; hsa-mir-5003-3p ; hsa-mir-6833-5p ; hsa-mir-7847-3p ; hsa-mir-3190-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-4795-5p ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-4519 ; hsa-mir-301b-3p ; hsa-mir-130b-3p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-454-3p ; hsa-mir-130a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-188-3p ; hsa-mir-195-3p ; hsa-mir-4733-5p ; hsa-mir-16-2-3p ; hsa-mir-577 ; hsa-mir-888-5p ; hsa-mir-376c-3p ; hsa-mir-421 ; hsa-mir-7159-5p ; hsa-mir-676-5p ; hsa-mir-505-3p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-7162-3p ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-6771-3p ; hsa-mir-1245b-3p ; hsa-mir-1249-5p ; hsa-mir-1257 ; hsa-mir-1321 ; hsa-mir-1343-5p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-3607-5p ; hsa-mir-3613-3p ; hsa-mir-4330 ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4790-3p ; hsa-mir-4802-5p ; hsa-mir-551b-5p ; hsa-mir-6081 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6515-5p ; hsa-mir-6783-5p ; hsa-mir-6797-5p ; hsa-mir-6799-5p ; hsa-mir-6824-5p ; hsa-mir-939-5p ; hsa-mir-942-5p

Nearest miRNA

hsa-mir-12113/Upstream/1510996; hsa-mir-1243/Downstream/6647288;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/13175, chr4-CpG: 51/Downstream/27427

Upstream sequence

gaatggaaagaattggaatggaaaggaatggaatcaccctgagtggaatggaatggaaaggaatggaatggaatggaaactaatgcaacggaaaggaaac

Downstream sequence

TCTAAAACTCAGTTACTCTCCTAACCAGTCTACTTAAGTGAATATATTTTTCCAGTCATCAAGACTAAGATTCAGTATAATGGAGTCATCTTTGTCTTTC