Basic Information
VIS ID
TVIS10009420
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1695
Orient
+
Integrated sequence
CCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGA| |CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAA
Host Sequence
Chromosome
chr9
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
90879933/88265018 (Hg38)
End
90879933/88265018 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/4295161; hsa-let-7a-1/Downstream/480818;
Nearest TSS
ENST00000422679/Upstream/290265; ENST00000462844/Downstream/123401;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/84353, chr9-CpG: 169/Downstream/122808
Nearby gene
SPATA31C2(-130033) ; SPIN1(+123364) ;
Upstream sequence
gttgcagagagccaagatcacaccactgcactccagcctgggcaacagagcgagactccatctcaaaaaaaaaaaaaaaaaaaaaaaattaaaaaatggt
Downstream sequence
CTGCTGCAGCCCCATGCTCTGTGCCCTCCCTGACTCTTGGGGCAGCTGTAAAGCTGGGATCTGCAGCTGCACCCTGGCCTCTCAGGAGCCACCATGTAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate