Basic Information
VIS ID
TVIS10009425
Fusion event
HBV-OR52A5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1809
Orient
-
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
5152963/5131733 (Hg38)
End
5152963/5131733 (Hg38)
Orient
+
Location type
Exonic
Target gene
OR52A5
Nearest miRNA
hsa-mir-210/Upstream/1275592; hsa-let-7a-2/Downstream/2103033;
Nearest TSS
ENST00000527297/Upstream/24203; ENST00000418080/Downstream/6518;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/523433, chr11-CpG: 32/Downstream/1102805
Upstream sequence
ATTATATTTAGGTTTTTACTTAGAACCAACCCTAAATCTCTATAGGAGTCACTAACGATCAAGTTACTTTTTTGAAGAAAAACACTTTCACAATATGGTC
Downstream sequence
ACGAATTTGCTTGGTCTTCACTCCATAGACAATAGGGTTGAGAAAAGGTGGGACTAACAGGTAAAGATTTGACAAGAGGATATGAATATATGGTGGTATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate