Basic Information
VIS ID
TVIS10009427
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
755
Orient
-
Integrated sequence
CAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTA| |TTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGA
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
49758819/52232449 (Hg38)
End
49758819/52232449 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/2105886; hsa-mir-122/Downstream/1004652;
Nearest TSS
ENST00000575820/Upstream/671628; ENST00000582595/Downstream/106576;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1034394, chr18-CpG: 29/Downstream/109558
Nearby gene
LINC01630(-669980) ; DCC(+107723) ;
Nearest cancer related gene
DCC(TSG, +107723) ;
Upstream sequence
aagagaagcaatgtaagaatgacaactgatttttcatctgaaactgtggtagccagaagctaacagagtaaaatctttaaagtgctaaaagaaaaaaaaa
Downstream sequence
taaatctgtcaatctagaattctataaccattgaaaatatttttcaatagttaatgcaaataaaagagactttctcagaccaacaaaatctaagagattt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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