Basic Information
VIS ID
TVIS10009433
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr3
Cytoband
q25.32
Reference genome
GRCh37/hg19
Start
157509543/157791754 (Hg38)
End
157509543/157791754 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA3D
Nearest miRNA
hsa-let-7g/Upstream/6225759; hsa-mir-1224/Downstream/1490892;
Nearest TSS
ENST00000440867/Upstream/248310; ENST00000468344/Downstream/186382;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/248319, chr3-CpG: 63/Downstream/302510
Nearby gene
PQLC2L(-190522) ; SHOX2(+304257) ;
Upstream sequence
ctgaggcaggagaatagcgtgaacccgggaggcggagctggcagtgagccgagattgcaccactccactccagcctgggtgacagagccagactccgtct
Downstream sequence
TGAGTTATTTTAAAGGATTGTCAGAAGACTATCAGGTCAGGACATTGAGCTTCATTCGCTATGCAGCTATGTTCCATGCTCCAATGTTGAGACACTGTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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