VISDB Viral Integration Site DataBase

VIS ID

TVIS10009437

Fusion event

HBV-NCOA2 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2991

Orient

-

Integrated sequence

CCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAG| |GAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCC

Chromosome

chr8

Cytoband

q13.3

Reference genome

Start

End

71126926/70214691 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-137 ; hsa-mir-193b-3p ; hsa-mir-544a ; hsa-mir-1185-5p ; hsa-mir-6864-5p ; hsa-mir-4471 ; hsa-mir-8059 ; hsa-mir-539-5p ; hsa-mir-3179 ; hsa-mir-7515 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-3120-3p ; hsa-mir-429 ; hsa-mir-200b-3p ; hsa-mir-200c-3p

Nearest miRNA

hsa-mir-124-1/Upstream/5835434; hsa-mir-10400/Downstream/4333852;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/142038, chr8-CpG: 251/Downstream/187219

Upstream sequence

TGAGTCAAATATTGTGAAGCTTCCAACACACCCCCCAGAGAATTTTTTCCTGTTGTCTCTACCTCCCTACTTATTTTGGCTCTTGTCTGCTTCACATTTC

Downstream sequence

TAAACAAACAGTCCAATTTCAACTAAAGTTTAAAAAGTTAATGGAATGGAAAAATATCAAAAGAGGCAAAATCTTCCATTAGAATGTGACAAAATAGTAA