Basic Information
VIS ID
TVIS10009439
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1907
Orient
+
Integrated sequence
CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA| |CATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCA
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
203957825/203988697 (Hg38)
End
203957825/203988697 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1985461; hsa-mir-1182/Downstream/1459605;
Nearest TSS
ENST00000473358/Upstream/125072; ENST00000525442/Downstream/52567;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/126924, chr1-CpG: 183/Downstream/84420
Nearby gene
SNRPE(-117545) ; LINC00303(+43750) ;
Upstream sequence
CTCTTTTGCATTTCTAGCCACTACACCCCACAAGATGACCCCGCCATTGCCAGTTAGATATCACCTCACCCCCAGCCTCAGAACTCACAGTTGTCTTTGA
Downstream sequence
ATTTATATTATTccatgggctgaattttgtcaccccacaactcatacgtcgaagccttaaccccagggtgatggtgtttggagacagagcctttgggaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate