Basic Information
VIS ID
TVIS10009440
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2659
Orient
+
Integrated sequence
ACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCA| |AAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTC
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
228041575/227853874 (Hg38)
End
228041575/227853874 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1H
Nearest miRNA
hsa-mir-101-1/Upstream/1931732; hsa-mir-1182/Downstream/87716;
Nearest TSS
ENST00000473358/Upstream/38181; ENST00000284523/Downstream/94024;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/37492, chr1-CpG: 32/Downstream/33802
Nearby gene
PRSS38(-7404) ; WNT9A(+67590) ;
Upstream sequence
AACTTCTACCATGGCGGGTATGAAAAGGGAATGGAGTGATAGCTACGGTGGGGAATATGAAAAGGGAATAGGGTTGGAGGGGACTCCCTGGAGCTCAGAA
Downstream sequence
TGTCCTCGATCTGACTCCAGATAGTTGTTACAAATGGGCTCACATGCACACAGATTCATTGAGCTGCTCCCTTAGAGTGTCCTCTTTACaaacgtaaatg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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