VISDB Viral Integration Site DataBase

VIS ID

TVIS10009444

Fusion event

HBV-PDE3A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

270

Orient

+

Integrated sequence

ATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCT| |CTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTT

Chromosome

chr12

Cytoband

p12.2

Reference genome

Start

End

20603843/20450909 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-128-3p ; hsa-mir-211-5p ; hsa-mir-3680-3p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-3915 ; hsa-mir-1224-5p ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-3928-3p ; hsa-mir-5582-3p ; hsa-mir-8055 ; hsa-mir-129-5p ; hsa-mir-4776-3p ; hsa-mir-1304-5p ; hsa-mir-4677-5p ; hsa-mir-192-3p ; hsa-mir-2116-5p ; hsa-mir-22-5p ; hsa-mir-3613-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-8485 ; hsa-mir-7150 ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-7843-3p ; hsa-mir-5585-5p ; hsa-mir-3191-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-942-5p ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-3128 ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-6814-5p ; hsa-mir-3614-3p ; hsa-mir-7849-3p ; hsa-mir-6818-3p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-377-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6846-3p ; hsa-mir-4743-3p ; hsa-mir-6888-3p ; hsa-mir-3182 ; hsa-mir-3120-5p ; hsa-mir-1237-3p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-361-5p ; hsa-mir-3171 ; hsa-mir-2115-3p ; hsa-mir-1265 ; hsa-mir-5692a ; hsa-mir-106a-3p ; hsa-mir-6844 ; hsa-mir-4684-3p ; hsa-mir-103a-2-5p ; hsa-mir-8066 ; hsa-mir-1267 ; hsa-mir-3147 ; hsa-mir-367-5p ; hsa-mir-4328 ; hsa-mir-4425 ; hsa-mir-450a-1-3p ; hsa-mir-4652-3p ; hsa-mir-4747-5p ; hsa-mir-5196-5p

Nearest miRNA

hsa-mir-1244-3/Upstream/2777515; hsa-let-7i/Downstream/3761512;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/80721, chr12-CpG: 97/Downstream/100682

Upstream sequence

GTTGAGCTGGTCAGGTCTCACTAGGGATTTGAAGAATAGCATAACAGCAAGTGGGCACCAAAGAAAAATTGAGTTTACTTGGATACACGAGAACTCTGCC

Downstream sequence

TTCTGACTTGGTCTGAGAACTTGTTCAAGGCAAGAAACAGTTTCTAACTTCAGCTGAATCACAGTGTGAAGGTGAACAAGTAAAAAAGCTCAGTTACCTG