VISDB Viral Integration Site DataBase

VIS ID

TVIS10009445

Fusion event

HBV-EIF4B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1795

Orient

+

Integrated sequence

CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAA| |TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT

Chromosome

chr12

Cytoband

q13.13

Reference genome

Start

End

53410851/53017067 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-16-5p ; hsa-mir-23b-5p ; hsa-mir-484 ; hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p

Nearest miRNA

hsa-mir-1244-3/Upstream/118083; hsa-let-7i/Downstream/39877;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/9955, chr12-CpG: 106/Downstream/29728

Upstream sequence

TCAGGCTGCTcgcgatggcttacacctgtaatcccagcactttgggaggccgaggtgggcagatcacatgagatgagaagttcaagaccagcctggccaa

Downstream sequence

catggtgaaaacccatctctactaaaaatacaaaaattagctgggcgtggtggcatgtgcctgtaatttcagctactcgggaggctggggcaggagaatt