Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009447
Fusion event
HBV-KIAA0100 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2245
Orient
+
Integrated sequence
AGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAG| |TTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGT
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
Start
End
26971551/28644533 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-421 ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-320a ; hsa-mir-181a-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-92a-3p ; hsa-mir-20a-5p ; hsa-mir-18a-5p ; hsa-let-7e-5p ; hsa-mir-195-5p ; hsa-mir-1185-5p ; hsa-mir-122-5p ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-383-5p ; hsa-mir-4257 ; hsa-mir-4645-3p ; hsa-mir-4690-3p ; hsa-mir-504-3p ; hsa-mir-5685 ; hsa-mir-6744-5p ; hsa-mir-6847-5p
Nearest miRNA
hsa-mir-1180/Upstream/283799; hsa-mir-10226/Downstream/216836;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/45039, chr17-CpG: 41/Downstream/616
Upstream sequence
ATCCCTCAAATTGTTATGAATCCCAGAGGCAGAGAGAGAAGACCCCAGCAAGAGTCAAAGCGGAGGCGGCTCTGTCACATGTGCCATCACACTCCCCAGA
Downstream sequence
GGGTCTGTCTGTCTCCTGCTCCCACCCTCCAGACAGGTATCCACGAGAAGGCACTTTGAGGTCAGACCCGGCAGCTCGAATGCTGTTCTCCCCAGACCGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.