VISDB Viral Integration Site DataBase

VIS ID

TVIS10009448

Fusion event

HBV-NEK8 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1789

Orient

-

Integrated sequence

GACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGG| |CATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGG

Chromosome

chr17

Cytoband

q11.2

Reference genome

Start

End

27066599/28739581 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-5089-5p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6882-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-4252 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-1273g-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6504-3p ; hsa-mir-512-3p ; hsa-mir-4438 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-1303 ; hsa-mir-6878-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-548s ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-4755-3p ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-4716-5p ; hsa-mir-4264 ; hsa-mir-622 ; hsa-mir-4781-3p ; hsa-mir-483-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-4713-5p ; hsa-mir-2355-5p ; hsa-mir-6131 ; hsa-mir-3663-5p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p

Nearest miRNA

hsa-mir-1180/Upstream/378847; hsa-mir-10226/Downstream/121788;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/10543, chr17-CpG: 99/Downstream/3939

Upstream sequence

ctctgttacccaggctagagtgcagtggcgtgatctcagctcactgcaacctccaccaccgggttcaagcgaatctcctgcctcagcctcccaagtagct

Downstream sequence

ggcattacaggcacccgccaccgcgcccagcaaatttttgtatttttagtagagacagggtttcaccatcttggccaggctggtctcgaactcctgacct