Basic Information
VIS ID
TVIS10009449
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1853
Orient
+
Integrated sequence
ATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTC| |ATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCG
Host Sequence
Chromosome
chr18
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
38649514/41069550 (Hg38)
End
38649514/41069550 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/1392771; hsa-mir-122/Downstream/3900532;
Nearest TSS
ENST00000575820/Upstream/1003264; ENST00000590220/Downstream/411518;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1227685, chr18-CpG: 180/Downstream/3609468
Nearby gene
MIR924HG(-1317555) ; KC6(+410722) ;
Upstream sequence
TTTGACATGGAATTACTTTTGTTTTATGCATCTATTAACCTTGAACTATCAGCATTTGTTTTAATGTTACAGGCTGAAGTGACCTAAATGTTCTTCTCTC
Downstream sequence
ATGCAGAGGGGATCTGTGATAGAATAGAGCATGTGGCCCGAGTTGGGGCTGGTCTTTAAGGGAAGGCAGAGTGTCTGTGACTGGAAGGACCACATTTCTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate