Basic Information
VIS ID
TVIS10009450
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
20933588/20750782 (Hg38)
End
20933588/20750782 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/351428; hsa-let-7e/Downstream/14371918;
Nearest TSS
ENST00000633603/Upstream/89186; ENST00000360204/Downstream/4468;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/698484, chr19-CpG: 19/Downstream/331576
Nearby gene
ZNF626(-89186) ; ZNF85(+172471) ;
Upstream sequence
agtgcaggaattccccaaacccaccaaggtggaagctcactggtgtcctccgcaatgtataacagccaccttgtggggtttccatactgcttctaataat
Downstream sequence
tgcaagatttcttgttgatattttatgtcttttcccccagagttcaataggcccttttctttacataatgctccatgcacttgaagggttaaaaagacat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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