VISDB Viral Integration Site DataBase

VIS ID

TVIS10009455

Fusion event

HBV-DHX57 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2306

Orient

+

Integrated sequence

GGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACC| |AAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCT

Chromosome

chr2

Cytoband

p22.1

Reference genome

Start

End

39050427/38823285 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-590-3p ; hsa-mir-23b-3p ; hsa-mir-98-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-15a-3p ; hsa-mir-125b-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7a-5p

Nearest miRNA

hsa-mir-1301/Upstream/3351799; hsa-mir-10b/Downstream/8554390;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/71743, chr2-CpG: 42/Downstream/52235

Upstream sequence

AGAGAATCGGTGTGTGGAGGTTCAATGAGCCGAGAGAACACAGACTGGAGATTATGAGCACTAAACATCTCTAAAATTTTAATTCTGAAAAGGAAACAAA

Downstream sequence

ATAATAATTTGTCAATTTTATTTCTGGTGGGATGACACAGAGGAATAATTTCTTTTGTGAGTGataataatttacaagtttaaataaaaaattttaaaat